The PROFILE_OPTION_NAME can be found by the SQL statement,
SELECT profile_option_name
FROM fnd_profile_options_tl
WHERE user_profile_option_name LIKE 'MO%'
It returns more than one row but i can make out that "ORG_ID" is the PROFILE_OPTION_NAME for MO: Operating Unit.
Inorder to know the Org_ID of the Org whose value is to be set in MO: Operating Unit the following SQL statement is used.
SELECT organization_id, NAME
FROM hr_all_organization_units;
From the above query the default Operating Unit is found and the below code below is used to set the profile option value using fnd_profile.save
DECLARE
stat BOOLEAN;
BEGIN
DBMS_OUTPUT.DISABLE;
DBMS_OUTPUT.ENABLE (100000);
stat := fnd_profile.SAVE ('ORG_ID', 286, 'SITE');
IF stat THEN
DBMS_OUTPUT.put_line ('Stat = TRUE - profile updated');
ELSE
DBMS_OUTPUT.put_line ('Stat = FALSE - profile NOT updated');
END IF;
COMMIT;
END;